Marburg virus, symptoms and routes of infection of the highly contagious disease reactivated in Africa

Marburg virus, symptoms and routes of infection of the highly contagious disease reactivated in Africa

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Since the pandemic Coronavirus landed in our lives, many others seem to follow. Diseases what did you think eradicatedor deactivated for years, make themselves felt buds in countries where they are not endemic. All these diseases that should be “eliminated” worry the organizations precisely because of their chained appearance at a time when we feel particularly vulnerable after the health crisis that we have experienced in the last two years. Of most concern so far has been the outbreak caused by the monkey pox, which is still active. Now the WHO has published one outbreak of Marburg virus after the first infections were confirmed in Ghana earlier this month July.

Since then it’s you two people have died and another 98 have been quarantined due to Marburg virus, raising fears of a massive outbreak of the disease highly contagious and deadly (up to 88%). It is about one zoonotic virus -Diseases and infections that can be transmitted between animals and humans-, from the family of filoviruses, the same as the dreaded virus Ebola.



The virus was first detected in Europe in particular in Marburg and Frankfurt, both German cities, and in the Serbian capital, Belgrade. In all three places this virus was registered in 1967. But, How is it spread and what are its symptoms?

symptoms

That incubation period It can last from 2 to 21 days and the following usually occur Symptom:

  • severe watery diarrhea
  • high fever
  • Strong headache
  • nausea
  • Vomit
  • General discomfort
  • Muscle aches
  • Stomach cramps
  • heavy bleeding
  • Orchitis: Inflammation of one or both testicles
  • acne
  • Late-stage external changes: “ghostly” facial features, sunken eyes, expressionless faces, and extreme lethargy
  • In which more serious cases Patients present with severe hemorrhagic manifestations. Bleeding in the nose, gums and vagina may occur
  • In fatal cases, this symptom usually affects multiple organs.

transmission paths

It is known that andthe fruit bat It acts as a natural host for the virus and is transmitted directly from these mammals to humans and then between humans. Then the tHuman-to-human transmission happens over direct contact from broken skin or mucous membranes with blood, secretions, organs or other body fluids from infected persons and with surfaces and materials contaminated with such liquids, e.g. B. Personal clothing or bedding.

That infected people Most people with Ebola or Marburg are critically ill, and before symptoms develop, transmission is very rare: high levels of virus are required for transmission, and people with high levels of virus are critically ill.

Because of this, and despite the fact that it is due to its gravity easily recognizableIt was confirmed that a team of WHO experts will provide coordination, risk assessment and infection prevention measures in the coming days. “The health authorities reacted quickly and prepared for a possible outbreak. This is good, because without immediate and decisive action Marburg can easily get out of hand. WHO is supporting health authorities on the ground and now that the outbreak has been declared we are allocating more resources to the response,” said Dr. Matshidiso Moeti, WHO Regional Director for Africa.

That average mortality rate of the disease is around 50%. During recent outbreaks, these rates have been in between 24% and 88% depending on the virus strain and the treatment of the cases. You rate a variety of possible treatments, including blood products, immunotherapies and drug therapies, and vaccine candidates with phase 1 data.

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